Solid solutions vs. solid dispersions: the impact of formulation parameters
نویسندگان
چکیده
منابع مشابه
Formulation & Evaluation of Oral Disintegrating Tablets of Lamotrigine Solid Dispersions
Lamotrigine is used in the treatment of CNS disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. Lamotrigine belongs to biopharmaceutical classification systems, BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...
متن کاملCharacterization of Olanzapine – Solid dispersions.
Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...
متن کاملCharacterization of Olanzapine – Solid dispersions.
Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...
متن کاملformulation & evaluation of oral disintegrating tablets of lamotrigine solid dispersions
lamotrigine is used in the treatment of cns disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. lamotrigine belongs to biopharmaceutical classification systems, bcs class ii (low solubility & high permeability). in addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...
متن کاملFormulation, Physicochemical Evaluation, and Dissolution Studies of Carbamazepine Solid Dispersions
Carbamazepine is a water-insoluble antiepileptic drug. Being a BCS class-II drug, its absorption is dissolution rate limited. Solid dispersions were prepared to enhance the dissolution rate of the drug. Crospovidone and croscarmellose sodium were used as the hydrophilic carriers. Solid dispersions showed a remarkable enhancement in the dissolution rate of the drug. In the present research work,...
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ژورنال
عنوان ژورنال: Journal Biomedical and Biopharmaceutical Research
سال: 2013
ISSN: 2182-2379
DOI: 10.19277/bbr.10.2.68